November 08, 2024

RESVERATROL, THE NATURAL ANTI-WRINKLE/ANTI-AGING MOLECULE!

Resveratrol is a molecule that has multiple health benefits for the human body, mainly for weight loss and allergic rhinitis. It is mainly found in red grapes and what is derived from them (e.g., wine and juices), It can also be found in a lower proportion in blackberries and blueberries. Some plants have a high concentration of this molecule, such as Asian Fallopia (also known as Japanese Knotweed and Asian Knotweed), commonly found in East Asia in Japan, China and Korea. However, many people prefer to consume Resveratrol in supplements or capsules that are easily available online.

This molecule, among its many applications to the human body, could help combat allergies such as rhinitis (Naso et al., 2024).

The consumption of resveratrol also seems to promote weight loss in overweight or obese people. It is commonly used when people have high cholesterol and problems with the myocardium (heart) (Khattar et al., 2022; Zhang et al., 2021).

is famous, not only for weight loss and for helping fight allergic rhinitis, but for reducing body pain and swelling. It helps the body fight diseases and expand blood vessels. also has estrogenic functions. It is able to improve cognitive and cerebrovascular functions in postmenopausal and menopausal women (Corbi et al., 2023).

Around the 1990s this molecule started to attract more interest, when it was suggested that it was linked to the cardioprotective effects of red wine (Cordova et al., 2005). Nowadays resveratrol is usually taken as a supplement, considering that intake in ranges from 700 to 1000 mg/kg body weight/day has no toxicological effects. (Vang et al., 2011)

Apart from all the benefits of resveratrol that have been mentioned above, it has been reported that it can activate a gene called SIRT1, the famous longevity gene, which is responsible for regulating the aging process. For that reason, resveratrol is called the longevity molecule by multiple sources (Ciccione et al., 2022).

Benefits on the skin!

Resveratrol helps prevent cellular oxidation, and the generation of sunspots. It turns out that this molecule can inhibit the genes responsible for melanogenesis! And not only that, but it also helps prevent the appearance of wrinkles. it is so good for the skin that it is included as a component in several cosmetic formulations (Zhang et al., 2021), it helps with acne symptoms, the production of collagen and elastin, and therefore skin regeneration, and it helps reduce skin irritations and superficial skin blemishes.

What makes resveratrol different?

When skin cells suffer damage from oxidation, the immune system acts to combat them. However, resveratrol activates these defenses without prior damage. That is, it does not act on the problem; it prepares the body to be better and avoid damage. For this reason, it is ideal for mature, weaker, and/or sensitive-to-deterioration faces.

Aside from all the benefits mentioned above, resveratrol also shows significant antibacterial effects against several foodborne pathogens (Listeria, Campylobacter, Staphylococcus aureus, and E. coli) [Ma et al., 2018].

Nowadays, it is important to consume natural antimicrobial drugs to substitute for antibiotics. One interesting alternative is resveratrol, which can be used to reduce the spreading of resistant bacterial strains. Resveratrol has shown antibacterial properties to important food-borne bacteria like E. coli, S. aureus, V. cholerae, C. jejuni, and L. monocytogenes that may mediate through cleavage of DNA. Resveratrol also minimizes cellular division, raising its potential use to ensure the high quality of several foods [Ma et al., 2018].

…a super interesting molecule!

After collecting and analyzing the scientific literature, one can conclude that it is well tolerated and favorably affects cardiovascular, neurological, and diabetic disorders. As such, it is possible that Re sveratrol can be considered the best nutritional additive and complementary drug, especially as a therapeutic candidate (Zhang et al., 2021), In humans, Re sveratrol is easily absorbed after oral administration (Bitterman et al., 2015).

Ongoing challenges and improvement

Resveratrol exhibits a wide array of beneficial biological activities, including antioxidant, anti-inflammatory, antidiabetic, cardioprotective, and antitumor effects. Its antioxidant properties, particularly in relation to cardiovascular health, inflammation, and metabolism, are well-documented. However, significant uncertainties and controversy remain regarding its overall efficacy, particularly due to challenges related to bioavailability, proper dosing, and mixed results from human clinical trials (Drago et al., 2024). Many clinical trials on resveratrol are ongoing or have returned inconclusive results, making it hard to establish definitive guidelines regarding its therapeutic dose and duration (Drago et al., 2024). Given the potential for medication interactions and individual variability in response, it is crucial to seek professional medical advice before use.

PLEASE NOTE: Here at Pristine’s, we care about your health. Therefore, Pristine’s recommends that you consult with your doctor before embarking on any significant alterations in your eating habits, nutritional supplement intake, or exercise routine. Our blogs are not able, nor intended, to substitute for professional, personalized medical advice. We ask that you discuss any points of interest raised in these blogs with a trusted medical professional.

We wish you optimal longevity and health.

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About the Author

Dr. Jorge A. Gutierrez, Ph.D. Chemical Sciences

Dr. Gutierrez is a Chemist with experience in nanobiotechnology, nanomedicine, biochemistry, and analytical chemistry. Over the years he has been involved in the development of novel products and formulations for human health.

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Images consulted in 2024-05-27 at www.unsplash.com