Revitalize and Rejuvenate: The Power of Age Renewal and Senolytics

               Over the years, age renewal and detoxification are gaining popularity, with more people striving hard to avoid aging problems and ensure they retain good health. As we age, our body undergoes various changes which affect our overall health and well-being. One of the major factors contributing to aging –other than the progressive physiological changes leading to senescence– is oxidative stress. Oxidative stress occurs as a result of an imbalance between the production of free radicals and the body's antioxidant defense systems. This imbalance causes cellular damage, inflammation, and the development of age-related diseases such as cardiovascular disease and cancer. Interestingly, oxidative stress is something that can be corrected, and this in turn results in a delay in the progression of aging (Ikeno & Flores, 2020; Pizzino et al., 2017). 

How does one combat "Oxidative Stress" to slow the "Aging" process? 

To reduce oxidative stress, one needs to get rid of the harmful free radicals to attain the right balance of these radicals in the body. This detoxification can further be aided by increasing the intake of antioxidants, which function as a scavenger for these free radicals and also enhance the activity of detoxifying enzymes (Gulcin, 2020). The intake of these antioxidants via natural food may not be sufficient to counteract oxidative stress, making the intake of supplements essential. Supplements such as fisetin, quercetin, curcumin, and zinc, have been proven to be effective antioxidants and thus help slow down the aging process.

Another effective method to combat the "Aging" process is by utilizing natural "Senolytics".

               Senolytics are natural substances designed to target and remove old cells. As we age, old cells build up in our body and cause “Senescence”, which is a process by which a cell ages and permanently stops dividing, but does not die. These old cells cause swelling and damage to our tissues. By getting rid of these cells, senolytics reduce swelling and help damage tissues to grow back, which can really slow down aging. Studies show that senolytics might even help people live healthier for a longer period of time, which is a really promising way to fight aging (Kirkland & Tchkonia, 2020).  

Are you interested in learning about natural ways to detoxify your body and slow down the “Aging” process? 

  Let me introduce you to some powerful "Senolytics" and "Antioxidant" agents that have been proven to do just that. By incorporating these agents into your routine, you can take control of your health and start feeling and looking your best. Let's explore them together! 

1. Fisetin: Fisetin, a natural flavonoid found in many fruits and vegetables, has gained attention for its senolytic properties. Studies have shown that fisetin can selectively target and eliminate senescent cells, promoting tissue regeneration and reducing inflammation. By incorporating fisetin supplements into your routine, you can potentially slow down the aging process and improve overall health. Additionally, it has also been shown to scavenge free radicals and reduce oxidative stress in the body, help improve the function of blood vessels, and reduce stiffness in large arteries (Mahoney et al., 2023). Studies have also shown that fisetin helps to protect against age-related cognitive decline, improves cardiovascular health, and also exhibits anti-inflammatory effects (Maher, 2015). Thus, fisetin is an ideal candidate for slowing down the aging process.

2. Quercetin: Quercetin is a bioflavonoid with strong antioxidant properties. It has been shown to reverse age-related cognitive deficits and chronic ethanol-induced retention deficits in mice (Singh et al., 2003). One of the key mechanisms through which quercetin functions as a senolytic is via its potent antioxidant properties. It scavenges free radicals and reduces oxidative stress, which is often elevated in senescent cells, leading to harmful effects due to their dysfunction. Quercetin is also known for its detoxifying properties. It aids in the elimination of toxins and heavy metals from the body, thereby reducing the burden on the liver and promoting overall detoxification. Senescent cells are known to promote a pro-inflammatory state in the body, contributing to chronic inflammation and age-related diseases. Quercetin exerts anti-inflammatory effects by inhibiting inflammatory pathways and reducing the secretion of pro-inflammatory molecules by senescent cells. Quercetin has been shown to support cellular health by enhancing mitochondrial function, regulating cell signaling pathways, and promoting DNA repair mechanisms. By improving the overall health and function of cells, quercetin can help in delaying the onset of aging-related changes and diseases (Chondrogianni et al., 2010; Yang et al., 2020). Moreover, quercetin has neuroprotective properties and potentially aids in reducing the risk of age-related neurodegenerative diseases (Barreca et al., 2016). Additionally, quercetin's anti-inflammatory action supports the body's defense against age-related inflammation and associated health complications. It also plays a role in the treatment of aging-related diseases, potentially through its interaction with SIRT1, a protein linked to aging processes (Cui et al., 2022). 

3. Curcumin: Curcumin, a compound found in turmeric, has a range of potential health benefits such as anti-inflammatory, antioxidant, and anti-aging effects. It has been shown to alleviate age-related symptoms, increase the lifespan in model organisms, and delay the onset of age-related disorders associated with cellular senescence. The molecular mechanisms underlying these effects are complex and involve inhibition of lipid peroxidation (free radicals attack lipids containing carbon-carbon double bond/s), which potentially delays the aging process (Karthika et al., 2023). Therefore, making it a prime candidate for longevity.
 

4. Zinc: Similar to curcumin, zinc also plays a crucial role in avoiding cognitive impairment and aging.  Zinc deficiency has been shown to result in neurodegenerative diseases, mental abnormalities, sleep disorders, tumors, vascular diseases, and other pathological conditions that cause cognitive impairment and premature aging. Zinc supplementation also decreases the incidence of infections, oxidative stress biomarkers, and inflammatory cytokines in the elderly (Sun et al., 2022). 

5. Choline: Choline is one of the essential nutrients required by the body and is obtained through one’s diet. It works as an anti-aging agent by supporting the liver and enhancing its ability to detoxify harmful substances (Mehedint & Zeisel, 2013). It also acts as an important nutrient for brain health and cognitive function, while protecting against the neural dysfunction that comes with aging (Blusztajn et al., 2017). Additionally, choline also plays a role in detoxification due to its oxidative properties.

Some other nutrients beneficial for “detoxification” and “anti-aging”: 

Additionally, other products such as milk thistle extract “Silymarin (SM)”, artichoke extract, dandelion leaf extract, chicory root inulin, yellow extract (Achillea millefolium), jujube fruit extract, and black pepper extract all support liver health and detoxification. They provide antioxidant and anti-inflammatory benefits, aiding in anti-aging and detox efforts, while black pepper extract also enhances nutrient absorption and dandelion protects against skin aging and also protects against  UVB damage  as well H2O2-induced cellular senescence (Hamza et al., 2020; Kazemi, 2015; Lin et al., 2020; Salekzamani et al., 2019; Shang et al., 2018; Surai, 2015; Yang & Li, 2015; Zhang et al., 2021). 

Hence, in the pursuit of age renewal and detoxification, the use of natural dietary supplements like fisetin, quercetin, curcumin, zinc and choline, in addition to milk thistle, artichoke extract, dandelion leaf extract, chicory root inulin, yellow extract (Achillea millefolium), jujube fruit extract, and black pepper extract will prove to be effective in combating the effects of aging and promoting overall wellness. These supplements ensure a power-packed supply of antioxidants and anti-inflammatory agents which aid in the reduction of oxidative stress, support cardiovascular health, and potentially reduce the risk of age-related cognitive decline. Integrating these supplements into a well-balanced and nutrient-dense diet will help combat the effects of aging and enhance overall well-being.

Here at Pristine’s, we care about your health. Therefore, Pristine’s recommends that you consult with your doctor before embarking on any significant alterations in your eating habits, nutritional supplement intake, or exercise routine. Our blogs are not able, nor intended, to substitute for professional, personalized medical advice. We ask that you discuss any points of interest raised in these blogs with a trusted medical professional.

We wish you optimal longevity and health.

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ABOUT THE AUTHOR

DR. Priyanka Guru, Ph.D. Health Sciences

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