AKG (Alpha Ketoglutaric Acid)
What is Alpha-Ketoglutarate (AKG)?
Alpha-Ketoglutarate (AKG) is a key intermediate in the Krebs cycle, which is essential for cellular energy production. AKG is involved in several biochemical pathways, including amino acid metabolism and the synthesis of neurotransmitters. It is also a precursor to glutamine and glutamate, important amino acids in the body.
What are the Benefits of AKG?
Energy Production: AKG enhances cellular energy production, improving overall energy levels and physical performance.
Muscle Recovery: It supports muscle repair and growth, making it popular among athletes and bodybuilders.
Anti-Aging: AKG has potential anti-aging effects, including improving mitochondrial function and reducing oxidative stress.
What Research is on AKG?
Research on AKG includes:
- Athletic Performance: Studies suggest that AKG supplementation can improve exercise performance, reduce muscle fatigue, and accelerate recovery.
- Longevity: Preliminary research indicates that AKG may have anti-aging benefits, such as improving mitochondrial function and extending lifespan in model organisms.
- Metabolic Health: AKG has been studied for its role in improving metabolic health, including reducing inflammation and oxidative stress.
What is the Mechanism of Action for AKG?
Krebs Cycle Participation: AKG is an integral part of the Krebs cycle, enhancing ATP production and cellular energy.
Nitrogen Scavenging: AKG helps remove excess nitrogen from the body, reducing the risk of ammonia toxicity and supporting overall metabolic health.
Antioxidant Properties: AKG acts as an antioxidant, reducing oxidative stress and protecting cells from damage.
What is the Typical Dosage of AKG?
Typical dosages of AKG range from 1-3 grams per day. Athletes and individuals seeking specific health benefits may adjust dosages based on their needs and health goals.
What Foods are Rich in AKG?
AKG is not naturally found in foods and is typically consumed as a dietary supplement.
Alabduladhem, Tamim O. and Bruno Bordoni. “Physiology, Krebs Cycle.” StatPearls, StatPearls Publishing, 23 November 2022.