Fisetin
What is Fisetin?
Fisetin is a natural flavonoid found in fruits and vegetables like strawberries, apples, persimmons, onions, and cucumbers. As a polyphenol, it is considered an antioxidant with potential health benefits.
What are the benefits of Fisetin?
Fisetin has been studied for its potential health benefits in a variety of areas. Some of the potential benefits of fisetin include:
- Antioxidant effects: Fisetin acts as a powerful antioxidant, neutralizing free radicals that contribute to aging and disease.
- Anti-inflammatory effects: Studies suggest anti-inflammatory properties, potentially beneficial for conditions like arthritis, asthma, and inflammatory bowel disease.
- Neuroprotective effects: Proposed neuroprotective properties may protect brain cells and improve cognitive function, potentially useful for conditions like Alzheimer's and Parkinson's disease.
- Anti-cancer effects: Research indicates potential anti-cancer effects, inhibiting the growth of cancer cells.
- Anti-aging effects: Fisetin is studied for its potential anti-aging effects by targeting and eliminating senescent cells, associated with age-related diseases.
It is important to note that more research is needed to fully understand the potential benefits of fisetin, and it should not be used as a substitute for medical treatment for any health condition.
What research is on Fisetin?
Studies have explored fisetin's effects on inflammation, cancer, cognitive function, aging, and metabolic health. While findings are promising, more research, especially in humans, is necessary for conclusive results.
What is the mechanism of action of Fisetin?
Fisetin's exact mechanism is not fully understood, but potential actions include antioxidant and anti-inflammatory activities, neuroprotection, senolytic activity targeting senescent cells, and anti-cancer effects.
Further research is needed to comprehensively understand fisetin's mechanisms and applications.
What is the typical dosage of Fisetin?
There is no established recommended daily dose of fisetin as it is not an essential nutrient. However, fisetin is available as a dietary supplement and the typical dose ranges from 100 to 1,000 mg per day, usually taken in divided doses.
It is always best to follow the dosage instructions on the supplement label and to consult with a healthcare provider before taking fisetin or any other dietary supplement, especially if you are pregnant, nursing, taking medication, or have a medical condition.
What food are rich in Fisetin?
Fisetin is found in various fruits and vegetables, including:
- Strawberries
- Apples
- Persimmons
- Grapes
- Kiwi
- Onions
- Cucumbers
- Tomatoes
- Kale
- Broccoli
- Gingko biloba leaves
However, it is important to note that the amount of fisetin in these foods is relatively small compared to the amount used in dietary supplements. For example, strawberries are one of the richest sources of fisetin in the diet, but it would take about 37 cups of strawberries to provide the amount of fisetin found in a typical 100 mg supplement dose.
Yousefzadeh, Matthew J et al. “Fisetin is a senotherapeutic that extends health and lifespan.” EBioMedicine vol. 36 (2018): 18-28. doi:10.1016/j.ebiom.2018.09.015