Spermidine
What is Spermidine?
Spermidine is a naturally occurring polyamine compound found in ribosomes and living tissues, essential for cellular growth and function. It is involved in various biological processes, including cell growth, differentiation, and apoptosis.
What are the Benefits of Spermidine?
- Cellular Longevity: Enhances autophagy, a cellular renewal process that removes damaged cells and promotes cell regeneration.
- Cognitive Function: May protect against neurodegenerative diseases and improve memory.
- Cardiovascular Health: Supports heart health and may reduce the risk of cardiovascular diseases.
- Immune Function: Boosts immune responses and may enhance the effectiveness of immune therapies​.
- Anti-Ageing Effects: Reduces oxidative stress and inflammation, contributing to overall anti-ageing effects.
What Research is on Spermidine?
Research on spermidine has shown its potential in promoting longevity and improving health span by enhancing autophagy and reducing oxidative stress. Studies have highlighted its role in boosting immune responses and its potential benefits in cancer therapy by improving the efficacy of immune checkpoint inhibitors​. Additional research indicates its neuroprotective properties, suggesting a role in preventing age-related cognitive decline and neurodegenerative diseases​.
What is the Mechanism of Action for Spermidine?
Spermidine operates through the induction of autophagy, a process that cleans out damaged cells and regenerates newer, healthier cells. It activates several molecular pathways involved in cellular maintenance and stress resistance, including the inhibition of histone acetyltransferases, which play a role in gene expression and protein function. Spermidine also influences the production and function of mitochondria, enhancing cellular energy and reducing oxidative stress.
What is the Typical Dosage of Spermidine?
There is no established RDA for spermidine. However, dietary intake from spermidine-rich foods and supplements is considered safe and beneficial. Typical supplemental dosages used in research range from 1 to 3 mg per day. As with any supplement, it is recommended to consult with a healthcare provider for personalized advice.
What Foods are Rich in Spermidine?
- Wheat Germ: One of the richest sources of spermidine.
- Soy Products: Tofu, natto, and soybeans.
- Mushrooms: Particularly shiitake mushrooms.
- Legumes: Lentils, peas, and chickpeas.
- Aged Cheese: Such as cheddar and parmesan.
- Vegetables: Broccoli, cauliflower, and green peppers.
Chamoto, Kenji et al. “Spermidine - an old molecule with a new age-defying immune function.” Trends in cell biology vol. 34,5 (2024): 363-370. doi:10.1016/j.tcb.2023.08.002