Pterostilbene
What is Pterostilbene?
Pterostilbene is a natural compound belonging to the stilbene family, similar to resveratrol, found in blueberries, grapes, and other berries. It has gained attention for its potential health benefits, particularly in promoting cardiovascular health, cognitive function, and antioxidant activity.
What are the Benefits of Pterostilbene?
Pterostilbene has many benefits:
- Antioxidant Properties: Pterostilbene exhibits strong antioxidant effects, protecting cells from oxidative stress and reducing the risk of chronic diseases associated with oxidative damage.
- Heart Health: It supports cardiovascular health by lowering cholesterol levels, improving blood vessel function, and reducing inflammation in the arteries.
- Cognitive Function: Pterostilbene may enhance cognitive function and protect against age-related cognitive decline by promoting brain cell health and reducing oxidative damage in the brain.
- Anti-inflammatory Effects: It has anti-inflammatory properties that help reduce inflammation throughout the body, contributing to overall health and disease prevention.
- Blood Sugar Regulation: Pterostilbene may help regulate blood sugar levels and improve insulin sensitivity, potentially benefiting individuals with diabetes or metabolic syndrome.
What Research is on Pterostilbene?
Research on Pterostilbene has explored its various health-promoting properties:
- Cardiovascular Health: Studies suggest that Pterostilbene can lower cholesterol levels, reduce blood pressure, and improve heart function, protecting against cardiovascular diseases.
- Cognitive Enhancement: Research indicates that Pterostilbene may enhance memory and cognitive function, potentially reducing the risk of neurodegenerative disorders like Alzheimer's disease.
- Antioxidant Activity: Pterostilbene demonstrates potent antioxidant activity, scavenging free radicals and protecting cells from oxidative damage implicated in aging and chronic diseases.
- Anti-inflammatory Effects: Studies show that Pterostilbene inhibits inflammatory pathways and reduces markers of inflammation in various tissues and organs.
What is the Mechanism of Action for Pterostilbene?
Antioxidant Activity: Pterostilbene neutralizes free radicals and reactive oxygen species, protecting cellular structures and DNA from oxidative damage.
Cardiovascular Benefits: It improves lipid metabolism, lowers LDL cholesterol levels, and enhances nitric oxide production, promoting blood vessel dilation and cardiovascular health.
Cognitive Protection: Pterostilbene crosses the blood-brain barrier and enhances brain cell function, supporting cognitive processes and reducing neuroinflammation.
Gene Expression: Pterostilbene influences gene expression related to antioxidant defenses and inflammation, contributing to its health-promoting effects.
What is the Typical Dosage of Pterostilbene?
Typical dosages of Pterostilbene in dietary supplements range from 50 mg to 250 mg per day, although higher doses may be used in specific therapeutic applications or under medical supervision. Dosage recommendations can vary based on individual health goals and conditions.
What Foods are Rich in Pterostilbene?
Pterostilbene is primarily found in dietary supplements derived from sources like blueberries, grapes, and other berries. It is less commonly obtained directly from food due to its relatively low concentration in natural sources.
Li YR, Li S, Lin CC. Effect of resveratrol and pterostilbene on aging and longevity. Biofactors. 2018 Jan;44(1):69-82. doi: 10.1002/biof.1400. Epub 2017 Dec 6. PMID: 29210129.